Affected ferrets typically need a new implant every year to a year and a half — a big improvement from the older treatment that often required monthly injections. In the current study, the duration of effectiveness, owner satisfaction and side effects of a gonadotrophin releasing hormone-agonist (deslorelin) implant were investigated during a two-year follow-up study in which 61 male and 69 female entire pet ferrets were given a 4.7 mg deslorelin implant as alternative to surgical neutering. Deslorelin implants may be useful in the long-term management of hormone-induced sequelae in ferrets with ACD and in treatment of animals that are considered at surgical or anesthetic risk. Ferrets with other health concerns that would not be good surgery candidates can be treated with Ferratonin Implants (Melatonin) and/or monthly injections of Lupron. This implant acts on the pituitary gland in … Single annual implant to manage pet ferret adrenal cortical disease (ACD) ACD is one of the most commonly diagnosed diseases in the domestic ferret (about 70% of ferrets in U.S. are affected) 3 This disease is caused by excessive secretion of the sex hormones progesterone, testosterone and estrogen by the adrenal gland 2,4; Active ingredient: deslorelin acetate Her ferrets are also prescribed melatonin to supplement the deslorelin. Suprelorin is given as an implant that slowly releases a continuous low dose of deslorelin. As a result in male dogs and ferrets less testosterone circulates in the blood, the dog and ferret stop producing sperm and its libido is reduced. Deslorelin (Suprelorin F) hormone implants aid in the treatment of adrenal gland disease in ferrets. Share. Active ingredient: Deslorelin Acetate. The musky odor in the ferrets which had received a deslorelin implant was less compared to the ferrets which were either surgically castrated or had received a placebo implant. Suprelorin 9.4 mg Implant for Dogs and Ferrets. The average time between treatment and symptom relapse was 13.6 months for surgery and 16.5 months for the implant. Tap to unmute. Deslorelin reliably blocks reproduction in both male and female ferrets and is an alternative to surgical neutering. Deslorelin may not decrease adrenal tumor growth in some treated ferrets. 1; Indications/Symptoms: Deslorelin is FDA-approved for inducing ovulation in estrual mares. Suprelorin F (4.7 mg) Implant is a controlled release implant containing the GnRH agonist deslorelin. This suppresses (blocks) the production of follicle stimulating hormone (FSH) and luteinising hormone (LH). * The preferred alternative is temporary chemical neutering by introducing a subcutaneous implant under the scruff (Suprelorin 4.7mg, or 9.4mg - deslorelin acetate implant). This condition, extremely common in middle-aged and senior ferrets, occurs when tumors form in one or both adrenal glands, resulting in the release of hormones that can cause hair loss, itchy skin, anemia, prostate gland enlargement in males (with potential fatal urinary tract obstruction), and bone marrow suppression. The implant is slightly bigger than a microchip. Concentration in oestradiol-17β decreased over an 8-week period. Jills (females) – effective for up to 43 months. THIS PRODUCT IS INDEXED - MIF # 900-013. Overall, the risks of Lupron and the Deslorelin/Suprelorin implant are very low. As a result, in male dogs and ferrets less testosterone circulates in the blood, the dog and ferret stop producing sperm and its libido is reduced. The Suprelorin ® F (4.7 mg) Implant comes pre-loaded in an implanting needle. With 4.7 mg implants, Suprelorin can effectively suppress the production of sex hormones (chemical neutering) for; Hobs (males) – effective for up to 16 months. Deslorelin (Suprelorin F) hormone implants aid in the treatment of adrenal gland disease in ferrets. Therapeutic indication: Pharmaceuticals: Hormones and therapeutically related products: GnRH products. In additional to the customer savings, The Avian & Exotic Animal Hospital will donate $5.00 dollars to Ferrets Anonymous for every Microchip special purchased during the month of February! 27 When intact male ferrets were treated with deslorelin implants, testosterone levels were markedly suppressed, and plasma levels of LH and FSH were below normal (compared with placebo-treated ferrets). SUPRELORIN F Implant is indicated for the management of adrenal gland cortical disease in the male and female domestic ferret only. Extra-label use is prohibited. This product must not be used in animals intended for use as food for humans or other animals. Do not use in animals intended for breeding. Ferret … You’ll notice that the first two studies used two different sizes in the implant: 3 mg and 4.7 mg. Published studies have shown that SUPRELORIN F Implant effectively manages the clinical signs of adrenal gland cortical disease in ferrets after implantation and remains effective for up to 1 year. As a result, in male dogs and ferrets less testosterone circulates in the blood, the dog and ferret stop producing sperm and its libido is reduced. They are produced by a company in Australia called Peptech. A newer implant treatment which has longer lasting effects than the Lupron or Melatonin is Deslorelin (Suprelorin). THE BEST TIME TO PLACE THE IMPLANT IS OCTOBER/NOVEMBER, WHEN FERRETS ARE NATURALLY ACYCLIC (no reproductive activity at all). As a general rule, it is used to prevent breeding, reduce aggression and reduce smell in males and to prevent breeding and prevent reproductive problems, eg hyperestrogenism, in females. Due to its sustained slow release action, this implant is effective in ferrets for a period of 6 months or up to several years depending on the severity of the disease process. (DESLORELIN ACETATE) 4.7 mg Implant. Suprelorin is given as an implant that slowly releases a continuous low dose of deslorelin. Deslorelin Implants for Ferrets and Birds. Deslorelin is an implant that can be placed beneath the ferret’s skin in a simple, quick surgical procedure. It slowly releases hormones over time to suppress the negative effects of the hormones released by the adrenal gland tumor or tumors. While the implant does not eliminate the tumor,... This is a savings of $63.00! Deslorelin: A newer treatment, similar to Lupron, is the deslorelin acetate (Suprelorin) implant. Deslorelin acetate has not been shown to reduce the size of adrenal tumors and is not considered curative. In fact, some ferret owners have reported that ferrets in which they previously were unable to control their BG became stable after treating the ferrets for adrenal disease. * A return to normalcy was reported at 8 weeks for hair loss, at 6 weeks for vulvar swelling, and at 2 weeks for skin disorders and sexual behavior. All of the implant ferrets responded to deslorelin, though it was only effective for one of the ferrets for 3 months. Suprelorin is given as an implant that slowly releases a continuous low dose of deslorelin. FOR USE IN FERRETS ONLY Info. However, the deslorelin implants have a number of advantages over Lupron Depot, and I am a huge fan of them. The trade name for these implants is Suprelorin, and the proper size for a ferret is the 4.7 mg implant. Current recommendations are that entire ferrets (if not to be bred with) or neutered ferrets have a deslorelin implant. LEGAL STATUS - In order to be legally marketed, a new animal drug intended for a minor species must be Approved, Conditionally Approved, or Indexed by the Food and Drug Administration. Deslorelin acetate suppresses the reproductive endocrine system, preventing production of pituitary and gonadal hormones. Species: Dogs, Ferrets. The implant suppresses the surge of sex hormones that occurs with the ferret’s natural breeding season. Melatonin is a hormone naturally produced in the brain when animals are exposed to darkness. Deslorelin implant hormone therapy to treat adrenal disease in ferrets. Adrenal disease, common in ferrets, is caused by cancer in the adrenal glands, resulting overproduction of sex hormones, leading to itchy skin, hair loss, and bone marrow suppression. In two international studies, female ferrets given 4.7 mg deslorelin implants suppressed oestrus between 17-27 months, and 22-35 months! In a study, jills in oestrus treated with a 4.7 mg deslorelin implant showed a significant decrease in oestrus signs 4 weeks later (vulvar oedema and behaviour) (Goericke-Pesch and Wehrend 2012). However, the deslorelin implants have a number of advantages over Lupron Depot, and I am a huge fan of them. It is also used as a treatment for adrenal disease in ferrets and rabbits and has also been used to treat ovarian cysts in guinea pigs; however, the mechanism of action is uncertain, and treatment failures have occurred. In ferrets, deslorelin is helpful in preventing the onset of adreno-cortical disease and in relieving symptoms of the disease in ferrets who are already affected. Lennox AM, Wagner R, Comparison of 4.7-mg deslorelin implants and surgery for the treatment of adrenocortical disease in ferrets, JEPM 21 (2012), pp 332.335. For more in-depth information on the management of adrenal gland diseases in ferrets, see handout "Hormonal Diseases in Ferrets". The Suprelorin® F (4.7 mg) Implant comes pre-loaded in an implanting needle. Watch later. This suppresses (blocks) the production of follicle stimulating hormone (FSH) and luteinising hormone (LH). If caused by an adrenal tumor, prostatic enlargement reduces very rapidly after removal of the tumor or after injections of leuprolide acetate or placement of a Deslorelin implant. Deslorelin implants are used in female ferrets too. Like leuprolide, deslorelin mimics GnRH and blocks adrenal stimulation. In one study, deslorelin implants were shown to be effective in blocking estrus in jills for at least 1 year, with no side effects. Lupron, a safe and effective treatment, must be given monthly for it to work. The implant in question is sold under the name brand of Suprelorin ® F and the component that make it work is deslorelin acetate (commonly referred to as “Des”). Newer research has shown that annual insertion of deslorelin (Suprelorin-F) implants in November or December may delay or prevent the onset of adrenal disease as the ferret matures. It has several uses and oftentimes owners and even vets may get them confused: This suppresses (blocks) the production of follicle stimulating hormone (FSH) and luteinising hormone (LH). The trade name for these implants is Suprelorin, and the proper size for a ferret is the 4.7 mg implant. This suppresses (blocks) the production of follicle-stimulating hormone (FSH) and luteinising hormone (LH). Deslorelin acetate implants are also prescribed for managing adrenal gland cortical disease in the male and female domestic ferret. Objective—To evaluate the clinical and endocrine responses of ferrets with adrenocortical disease (ACD) to treatment with a slow-release implant of deslorelin acetate.. Animals—15 ferrets with ACD.. Procedure—Ferrets were treated SC with a single slow-release, 3-mg implant of deslorelin acetate.Plasma estradiol, androstenedione, and 17-hydroxyprogesterone concentrations were … The advantage of deslorelin over leuprolide is that the implant lasts for up to 2 years in the average ferret. As a result, in male dogs and ferrets less testosterone circulates in the blood, the dog and ferret stop producing sperm and its libido is reduced. Suprelorin is given as an implant that slowly releases a continuous low dose of deslorelin. Suprelorin® F (4.7 mg) Implant is a synthetic GnRH analogue (deslorelin acetate) in a biocompatible, slow release subcutaneous implant. The implant is a solid, opaque, white to pale yellow cylinder, 2.3 mm × 12.5 mm in length and weighing 50 mg. Extra-label use is prohibited. Copy link. Our implant special includes a Physical Examination, brief anesthesia and Delslorelin implant. Shopping. The implant is a solid, opaque, white to pale yellow cylinder, 2.3 mm × 12.5 mm in length and weighing 50 mg. Product: Suprelorin 9.4 mg Implant for Dogs and Ferrets. Suprelorin ® F (4.7 mg) Implant is a synthetic GnRH analogue (deslorelin acetate) in a biocompatible, slow release subcutaneous implant. Deslorelin implants have been researched with great extent in ferrets and their used is common for the prevention and treatment of a number of conditions.

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